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Unfortunately, if you stop down too far in search of DOF, you start getting difraction effects that soften the whole image.
I used to do a lot of close up 5 x 7 photography using a process lens with a max aperture of f 11 (Min of f 90 as I recall). As you got to f 64 and higher, you'd get more DOF, but it began to get mushy.
And getting enough light was always a bear. The only good news was that the stuff I was photographing wasn't moving so I could use long exposures
But reciprociy failure would set in at long exposure times - ie there was minimal advantage to a 100 minute exposure compared to a 10 minute exposure. If not an actual disadvantage. And shadows tend to move as the sun moves during a long exposure.
I guess nothing is perfect.
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