I have a father of the groom reviewing a wedding highlight of his son and he asked me if it was possible to remove the acne on his sons face in a few shots. I'm sure this is possible somehow but I don't know how.

Is this a realistic request?

Include a bottle a Clearasil with the dvd. Lol

I once had a client ask me to edit the video to make her less fat.

Maybe in after effects by placing a mask over the acne and track the face? I had a bride last year with acne, in such a case I stay clear from extreme closeups and just keep more distance.

There are some "digital makeup" plugins available that give varying results. I have one from FCPeffects.com and it kinda sorta works sometimes: https://www.fcpeffects.com/collections/new-stuff/products/skin-smoother-2

Photoshop can handle video. Use Healing brush on a layer and setup an action.

Maybe in after effects by placing a mask over the acne and track the face? I had a bride last year with acne, in such a case I stay clear from extreme closeups and just keep more distance.
good point
I'm more sensitive to this now. One should never lose sight of filming what's most flattering that means a wider shot for the older less attractive.

i have some of the sheffield softworks plugins, which include several digital makeup programs. Pretty incredible. should be able to get a trial to see if they work for you.

There are some Mocha tutorials around showing how to do this. Not sure I'd get Mocha just for this, but the AE version will probably do it.

You could also try Beaty Box from Digital Anarchy. Works with Premiere, FCP 7 & X, Resolve, Vegas, AE, etc.

Demo version available.

Info, examples, tutorials, etc:

https://digitalanarchy.com/beautyVID/main.html

Thanks for the suggestions everyone! I just told him I couldn't remove acne in video like they can in photos and he was fine with it.