My setup is:
C:\ - operation system, appplications drive...
D:\ - Project files, rendering drive...

I wonder if its better to have this setup instead?
c:\ - Operationsystem, application drive
d:\ - project files drive
e:\ - rendering drive

Would this setup boost in performence, or wouldnt it be any differens...?

You should see a marginal speed increase since you wouldn't be reading and writing to/from the same drive.

That's how I do it. Works fine for me.

...I wonder if its better to have this setup instead?
c:\ - Operationsystem, application drive
d:\ - project files drive
e:\ - rendering drive

Would this setup boost in performence, or wouldnt it be any differens...?

I would format d: & e: to raid 0 for project media files and rendering. Then you would have the benefit of accessing 2 drives when editing as well as when rendering.

Ok... I really hate RAID 0, it feels so unsafe...

If clusters gets lost one one harddrive, you lose it all on both...
I have never used tis settings myself, but I can feel the terror if one disc would get corrupted or sometihng...

I have C: 250G Boot drive with OS and Applications, D: 250G Temp, project data and Preview for all programs, E: 750G video storage, F: 750G video storage and two external 500G eSata drives for storage when needed. I also do not like RAID since most of my projects are multicam a RAID is actually slower than two drives with the cam files assigned to the two drives. A RAID has about 1.7 times the performance of a single drive so when multiple files are being read simultaneously( PiP's or while editing multicam) two separate drives will be faster if these files are on different drives in a contiguous file. The drive will not have to seek for the data as much as a RAID. The RAID will win when only one file is being used and the file is uncompressed or an intermediate codec with a high data rate requirement. This too may be marginal as most SATA 11 drives have sustained throughput of more than 50MBs plenty for DV ,HDV and most intermediate codecs. The RAID as one other advantage it looks like just one big drive so one doesn't have to be concerned about where to put the file. The downside is have a problem on a drive and everything is lost.

Ron Evans