have a vista 64 core i7 running 12 gigs of ram on premiere 4.1 and when i am previewing a series of edited clips, my computer makes the mouse usb disconnect and reconnect sound and stops the play. everything is running amazing except for this annoying thing... especially when i am showing a client and it keeps stopping every 5 seconds. anyone have any ideas?

You can try a PS2 mouse, and see if it still happens.

yeah i know but was hoping that it was something simple... sounds to me like some conflict in motherboard but i am not that much of a computer guy

Bad mouse connection? What happens if you use just the keyboard?

I've had exactly the same problem. I tried updating the mouse drivers, as well as changing the USB port.
In the end, I found out that was an intermittent break in the mouse cable near to the mouse itself, where the cable had been bending...

using the keyboard or my shuttle xpress no matter what i am playing it keeps stopping. the only thing is its a wireless usb. i thought it would be a distance thing with the dongle but that didnt help and its the second keyboard tried.

Wireless doesn`t always play nice with time-critical applications, including editing apps. Avoid wireless keyboards and mice (mouses? :))

i always have used wired and knew it would be a place for possible issues but figured i would give it a shot... lesson learned