I used to use Procoder 3 & Sorenson Squeeze for final compression, but lately I'm finding that the CS4 version of Adobe Media Encoder is doing a great job of compression for BR, Flash, and DVD.
Another tip for DVD output: If you are in CFHD.avi 60i, it is better to downscale the HD master .avi to a CF SD 60i .avi master and make your m2v transcode from the SD master.
Cineform HD link does a superior job of downscaling interlaced CFHD to SD.
You can really see the difference.

hvx200's do it for a living.

think of intelligent image resizing, spatially interpolating slow motion plugins, etc. There's a ton of pretty well written algorithms out there that do, in my opinion, a darn good job of calculating something from nothing. Why there shouldn't be one for color sampling is beyond me.

Also, color interpolation is a very new and interesting idea to me. While thinking about interpolation in general, I got to thinking about if anybodys written anything to get smoother results out of 4:2:0 footage, and some googling led me to this post. Looks like some software is already doing it.

Also, I found this pretty interesting article - Improved Color Subsampling

He talks about how programs are already interpolating compressed color, and how he has written his own algorithm that's doing it much better. Look at how much he recovered from the dv compressed image, crazy

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